T-Bet/TBX21 (D6N8B) Rabbit Monoclonal Antibody (Alexa Fluor^®488 Conjugate)#14298,Cell Signaling Technology (CST),14298

TheT-boxgene family consists of transcription factors characterized by a related DNA-binding domain (T-box) of approximately 200 amino acids (1,2). TheT-boxgenes exhibit diverse temporal and spatial patterns in the developing embryo. Studies have demonstrated members of this family play crucial roles during embryogenesis in a wide range of organisms by regulating cell fate decisions to establish the early body plan and to regulate later processes underlying organogenesis (3-5). Mutations inT-boxgenes are associated with many developmental defects (6). Recent studies also indicate potential roles in cancer by members of the T-box family (7-9).Wilkinson, D.G. et al. (1990)Nature343, 657-9.Papaioannou, V.E. and Silver, L.M. (1998)Bioessays20, 9-19.Showell, C. et al. (2004)Dev Dyn229, 201-18.Papaioannou, V.E. (2001)Int Rev Cytol207, 1-70.Hoogaars, W.M. et al. (2007)Cell Mol Life Sci64, 646-60.Baldini, A. (2004)Curr Opin Cardiol19, 201-4.Abrahams, A. et al. (2010)IUBMB Life62, 92-102.Rowley, M. et al. (2004)J Mammary Gland Biol Neoplasia9, 109-18.Yang, X.R. et al. (2009)Nat Genet41, 1176-8.Alternate NamesT-bet; T-box 21; T-box expressed in T cells; T-box protein 21; T-box transcription factor 21; T-box transcription factor TBX21; T-cell-specific T-box transcription factor T-bet; T-PET; TBET; TBLYM; TBX21; Transcription factor TBLYM

T-bet; T-box 21; T-box expressed in T cells; T-box protein 21; T-box transcription factor 21; T-box transcription factor TBX21; T-cell-specific T-box transcription factor T-bet; T-PET; TBET; TBLYM; TBX21; Transcription factor TBLYM