TDP43 Antibody (YA6195),MedChemexpress,HY-P86503

TDP43 is an RNA-binding protein that preferentially binds to GU-repeats on RNA molecules via its two RNA recognition motifs, RRM1 and RRM2, predominantly localized within long introns and the 3'UTR of mRNAs. It regulates the splicing of various non-coding and protein-coding RNAs, including proteins involved in neuronal survival and mRNAs encoding proteins relevant to neurodegenerative diseases. TDP43 maintains mitochondrial homeostasis by regulating the processing of mitochondrial transcripts and controls mRNA stability by recruiting CNOT7/CAF1 deadenylase to mRNA 3'UTRs, leading to poly(A) tail deadenylation and shortening. Under oxidative stress, TDP43 associates with stalled ribosomes in stress granules (SGs) to promote cell survival. It also plays a role in skeletal muscle formation and regeneration by forming cytoplasmic myo-granules and binding mRNAs encoding sarcomeric proteins. TDP43 contributes to circadian clock periodicity by stabilizing CRY1 and CRY2 proteins in an FBXL3-dependent manner and negatively regulates CDK6 expression. Additionally, it modulates the expression of HDAC6, ATG7, and VCP in a PPIA/CYPA-dependent manner.