TET1 antibody [N1], N-term,Genetex,GTX125888

Host

Rabbit

Reactivity

Mouse

Application

WB ICC/IF IHC-P IHC-Wm IP ChIP assay

Conjugate

Unconjugated

Platform ID

BAB900348529

Genetex

Headquarters

2456 Alton Pkwy Irvine, CA 92606 USA

Genetex

Contact

Tel: 1-949-553-1900
Fax: 1-949-309-2888

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameTET1 antibody [N1], N-term
Cat. No.GTX125888
Gene ID (Entrez)52463
HostRabbit
IsotypeIgG
ReactivityMouse
ConjugationUnconjugated
ApplicationWB ICC/IF IHC-P IHC-Wm IP ChIP assay
ClonalityPolyclonal
Concentration0.79 mg/ml (Please refer to the vial label for the specific concentration.)
TargetTet1
ImmunogenRecombinant protein encompassing a sequence within the N-terminus region of mouse TET1. The exact sequence is proprietary.
PurityPurified by antigen-affinity chromatography.
Appearance/FormLiquid
FormulationPBS, 20% Glycerol,0.025% ProClin 300
StorageStore as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Regulatory StatusResearch Use Only

Scientific Background

Dioxygenase that specifically binds methylcytosine (5mC), a minor base in mammalian DNA found in repetitive DNA elements that is crucial for retrotransposon silencing and mammalian development. Catalyzes the conversion of methylcytosine (5mC) to 5-hydroxymethylcytosine (hmC). The clear function of 5-hydroxymethylcytosine (hmC) is still unclear but it may influence chromatin structure and recruit specific factors or may constitute an intermediate component in cytosine demethylation. 5-hydroxymethylcytosine (hmC) is present in ES cells and is enriched in the brain, especially in Purkinje neurons. May play a role in the fetal development of heart, lung and brain.

Synonyms

tet methylcytosine dioxygenase 1 , 2510010B09Rik , AA517754 , BB001228 , Cxxc6 , D10Ertd17e , LCX , mKIAA1676

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