TFRC Recombinant Antibody, AbBy Fluor-680 Conjugated,Bioss,bsm-52793r-bf680-100ul

Host

Rabbit

Reactivity

Human, Rat

Application

WB

Conjugate

AbBy Fluor-680

Platform ID

BAB468163203

Bioss

Headquarters

300 Tradecenter Dr, ste 4610Woburn, Massachusetts 01801 - U.S.A.

Bioss

Contact

Tel: +1.781.569.5821
Fax: +1.781.731.9286

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameTFRC Recombinant Antibody, AbBy Fluor-680 Conjugated
Cat. No.bsm-52793r-bf680-100ul
Accession NumberP02786
Gene ID (Entrez)P02786
HostRabbit
IsotypeIgG
ReactivityHuman, Rat
ConjugationAbBy Fluor-680
ApplicationWB
Working DilutionsWB:1:300-5000
ClonalityRecombinant
ConcentrationLot dependent
PurityPurified by Protein A.
FormulationAqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
StorageStore at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Scientific Background

Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.

Synonyms

Transferrin receptor protein 1, T9, p90, CD_antigen: CD71, TR, TfR, TfR1, Trfr, TFRC

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