TLS/FUS Antibody (YA6232),MedChemexpress,HY-P86540

TLS/FUS is a DNA/RNA-binding protein involved in multiple cellular processes including transcription regulation, RNA splicing, RNA transport, DNA repair, and damage response. It specifically binds single-stranded RNA containing the 5'-AGGUAA-3' consensus sequence and interacts with nascent pre-mRNAs, serving as a molecular bridge between RNA polymerase II and U1 small nuclear ribonucleoprotein to couple transcription with splicing. The protein autoregulates its expression by binding its own pre-mRNA via nonsense-mediated decay. During DNA double-strand break repair, it promotes D-loop formation and homologous recombination. In neuronal cells (by similar), it plays essential roles in dendritic spine formation/stability, RNA transport, mRNA stability, and synaptic homeostasis.