TMEM106B (F4D8C) Rabbit Monoclonal Antibody#87851,Cell Signaling Technology (CST),87851

Transmembrane protein 106B (TMEM106B) is a type II transmembrane protein with unknown function (1).TMEM106Bwas first identified as a major risk factor in genome-wide association studies in patients with frontotemporal lobar degeneration (FTLD), a neurodegenerative disorder characterized by atrophy in the frontal and temporal lobes of the brain (2). Localization of TMEM106B in late endosomal/lysosomal compartments suggests a role in regulating endo-lysosomal morphology and function (3). Endo-lysosomal dysfunction is likely a major cellular pathway that contributes to FTLD as other genetically linked FTLD genes, includingC9orf72,GRN, andMAPT, converge on this cellular pathway (4). TMEM106B is sequentially processed through ectodomain shedding, followed by intramembrane proteolysis, with possible variability in the intramembrane cleavage site. Fragments consisting of residues 120–254 of TMEM106B have been shown to form amyloid filaments in human brains (5-7).ÂLang, C.M. et al. (2012)J Biol Chem287, 19355-65.Van Deerlin, V.M. et al. (2010)Nat Genet42, 234-9.Brady, O.A. et al. (2013)Hum Mol Genet22, 685-95.Root, J. et al. (2021)Neurobiol Dis154, 105360.Schweighauser, M. et al. (2022)Nature605, 310-314.Chang, A. et al. (2022)Cell185, 1346-1355.e15.Held, S. et al. (2025)Cell Rep44, 115107.Alternate NamesFLJ11273; HLD16; MGC33727; T106B; TMEM106B; TMEM106B protein; Transmembrane protein 106B

FLJ11273; HLD16; MGC33727; T106B; TMEM106B; TMEM106B protein; Transmembrane protein 106B