TNF Receptor 2 Antibody (YA3868),MedChemexpress,HY-P84171

TNF Receptor 2 Antibody (YA3868) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to TNF Receptor 2.

Host

Mouse

Reactivity

Human,Mouse

Application

WB,FC,ELISA

Conjugate

Non-conjugated

Platform ID

BAB462050508

Suppliers

(1)

Biomedical Life sciences

91-9676853503

[email protected]
Country:India
City:Madīnat Ḩamad
Plot No.A-2811121/A&B/3.IP NACHARAM. ALA NACHARAM, Road N0-15, Hyderabad Medchal Malkajgiri, Telangana-500076
Master of Bioactive Molecules

MedChemexpress

Master of Bioactive Molecules

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Contact

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Email:

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Product Specifications
Scientific Background
Synonyms

Specifications

NameTNF Receptor 2 Antibody (YA3868)
Cat. No.HY-P84171
Accession NumberP20333
Gene ID (Entrez)7133
HostMouse
IsotypeIgG2b
ReactivityHuman,Mouse
ConjugationNon-conjugated
ApplicationWB,FC,ELISA
Working DilutionsWB: 1:500-1:2000; FC: 1:200-1:400; ELISA: 1:10000
ClonalityMonoclonal Antibody
Clone NumberYA3868
Molecular WeightPredicted band size: 48 kDa; Observed band size: 65 kDa
ImmunogenPurified recombinant fragment of human CD120B (AA: extra 23-257) expressed in E. Coli.
Purityaffinity purified.
Appearance/FormLiquid
ShippingShipping with blue ice.
FormulationSupplied in PBS with 0.05% sodium azide
StorageStored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Regulatory StatusResearch Use Only

Scientific Background

CD120B is a receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, suggesting that it regulates TNF-alpha function by antagonizing its biological activity.

Synonyms

TNFRSF1B; p75; TBPII; TNFBR; TNFR2; TNFR1B; TNFR80; TNF-R75; p75TNFR; TNF-R-II

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