TNF Receptor II antibody [4G22],Genetex,GTX53028

The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008]

CD120b , TBPII , TNF receptor superfamily member 1B , TNFBR , TNFR1B , TNFR2 , TNFR75 , TNFR80 , TNFRII , TNFRSF1B , p75 , p75TNFR , TNF receptor II