TNF Receptor II antibody [HM102],Genetex,GTX27369

Host

Rat

Reactivity

Mouse

Application

WB IHC-Fr FCM IP ELISA Activation

Conjugate

Unconjugated

Platform ID

BAB432483097

Genetex

Headquarters

2456 Alton Pkwy Irvine, CA 92606 USA

Genetex

Contact

Tel: 1-949-553-1900
Fax: 1-949-309-2888

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameTNF Receptor II antibody [HM102]
Cat. No.GTX27369
Gene ID (Entrez)7133
HostRat
IsotypeIgG2a
ReactivityMouse
ConjugationUnconjugated
ApplicationWB IHC-Fr FCM IP ELISA Activation
ClonalityMonoclonal
Concentration100 μg/ml (Please refer to the vial label for the specific concentration.)
TargetTNFRSF1B
ImmunogenThe monoclonal antibody HM102 recognizes the extracellular part of membrane-bound TNF Receptor II as well as the soluble form of TNF Receptor II which is generated by proteolytic cleavage of the extracellular domain.
PurityProtein G purified
Appearance/FormLiquid
FormulationFilter-sterilized PBS, 0.1% BSA,No preservatives
StorageStore as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.
Regulatory StatusResearch Use Only

Scientific Background

The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008]

Synonyms

CD120b,TBPII,TNF receptor superfamily member 1B,TNFBR,TNFR1B,TNFR2,TNFR75,TNFR80,TNFRII,TNFRSF1B,p75,p75TNFR,TNF receptor II

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