TNF-alpha IHC Antibody,IHC WORLD,IW-PA1079

Host

Rabbit

Reactivity

Human, mouse, rat.Not tested in other species.

Application

IHC-P

Conjugate

Unconjugated

Platform ID

BAB775683109

IHC WORLD

Headquarters

3225 Corporate Court Ellicott City, Maryland 21042

IHC WORLD

Contact

Tel: 443-686-9618
Fax: 443-638-0394

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameTNF-alpha IHC Antibody
Cat. No.IW-PA1079
HostRabbit
IsotypeIgG
ReactivityHuman, mouse, rat.Not tested in other species.
ConjugationUnconjugated
ApplicationIHC-P
Clone NumberPolyclonal
ImmunogenA synthetic peptide corresponding to a sequence at the C-terminal of human TNFalpha, different from the related mouse sequence by five amino acids, and rat sequence by seven amino acids.
PurityImmunogen affinity purified
Appearance/FormReady to use solution in PBS with stabilizer and 0.01% sodium azide. No further dilution needed. Serum blocking step should be omitted.
StorageStore at 2-8°C. Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

TNFα (Tumor Necrosis Factor alpha) gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.

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