TNF alpha Monoclonal Antibody,Bioss,bsm-0387m

Host

Mouse

Reactivity

Human

Application

WB, IHC-P, IF(IHC-P)

Conjugate

Unconjugated

Platform ID

BAB627820324

Bioss

Headquarters

300 Tradecenter Dr, ste 4610Woburn, Massachusetts 01801 - U.S.A.

Bioss

Contact

Tel: +1.781.569.5821
Fax: +1.781.731.9286

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameTNF alpha Monoclonal Antibody
Cat. No.bsm-0387m
Accession NumberP01375
Gene ID (Entrez)7124
HostMouse
IsotypeIgG
ReactivityHuman
ConjugationUnconjugated
ApplicationWB, IHC-P, IF(IHC-P)
Working DilutionsWB:1:300-5000 | IHC-P:1:200-400 | IF(IHC-P):1:50-200
ClonalityMonoclonal
Concentration1ug/ul
PurityPurified by Protein G.
Formulation0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
StorageShipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Scientific Background

Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.

Synonyms

DIF; TNFA; TNFSF2; TNF-alpha; Tumor necrosis factor; Cachectin; Tumor necrosis factor ligand superfamily member 2; TNF-a; TNF

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