TREM2 (E7O7Q) Rabbit Monoclonal Antibody (Alexa Fluor^®488 Conjugate)#31944,Cell Signaling Technology (CST),31944

The triggering receptor expressed on myeloid cells 2 (TREM2) protein is an innate immune receptor that is expressed on the cell surface of microglia, macrophages, osteoclasts, and immature dendritic cells (1). The TREM2 receptor is a single-pass type I membrane glycoprotein that consists of an extracellular immunoglobulin-like domain, a transmembrane domain, and a cytoplasmic tail. TREM2 interacts with the tyrosine kinase-binding protein DAP12 to form a receptor-signaling complex (2). The TREM2 protein plays a role in innate immunity and a rare functional variant (R47H) of TREM2 is associated with the late-onset risk of Alzheimer’s disease (1,3). Research studies using mouse models of Alzheimer’s disease indicate that deficiency and haploinsufficiency of TREM2 can lead to increased β-amyloid (Aβ) accumulation as a result of dysfunctional microglial response (4). These results agree with the distribution of TREM2 in human brain regions (e.g., white matter, the hippocampus, and neocortex) that are involved in Alzheimer's disease pathology (2). In addition, amyloid plaque formation induces expression of TREM2 and amyloid phagocytosis (5). Loss-of-function mutations in the correspondingTREM2orDAP12genes can result in Nasu-Hakola disease, a rare form of progressive presenile dementia that results from polycystic osseous lesions (6). TREM2 membrane shedding occurs by cleavage at the extracellular site between H157/S158, generating an N-terminal shedded fragment and a membrane bound C-terminal fragment (7,8).tColonna, M. (2003)Nat Rev Immunol3, 445-53.Jonsson, T. et al. (2013)N Engl J Med368, 107-16.Boutajangout, A. and Wisniewski, T. (2013)Int J Cell Biol2013, 576383.Wang, Y. et al. (2015)Cell160, 1061-71.Melchior, B. et al. (2010)ASN Neuro2, e00037.Klünemann, H.H. et al. (2005)Neurology64, 1502-7.Thornton, P. et al. (2017)EMBO Mol Med9, 1366-1378.Schlepckow, K. et al. (2017)EMBO Mol Med9, 1356-1365.Alternate NamesOTTMUSP00000023119; Trem; TREM-2; Trem2; Trem2a; Trem2b; Trem2c; Triggering receptor expressed on monocytes 2; Triggering receptor expressed on myeloid cells 2; triggering receptor expressed on myeloid cells 2a; triggering receptor expressed on myeloid cells 2b; triggering receptor expressed on myeloid cells 2c

OTTMUSP00000023119; Trem; TREM-2; Trem2; Trem2a; Trem2b; Trem2c; Triggering receptor expressed on monocytes 2; Triggering receptor expressed on myeloid cells 2; triggering receptor expressed on myeloid cells 2a; triggering receptor expressed on myeloid cells 2b; triggering receptor expressed on myeloid cells 2c