TRIM28 Recombinant Antibody,Bioss,bsm-63000r-100ul

Host

Rabbit

Reactivity

Human, Mouse, Rat

Application

WB, FCM, IHC-P, IHC-F, IF(IHC-P), IF(ICC)

Conjugate

Unconjugated

Platform ID

BAB139753329

Bioss

Headquarters

300 Tradecenter Dr, ste 4610Woburn, Massachusetts 01801 - U.S.A.

Bioss

Contact

Tel: +1.781.569.5821
Fax: +1.781.731.9286

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameTRIM28 Recombinant Antibody
Cat. No.bsm-63000r-100ul
Accession NumberQ13263
Gene ID (Entrez)10155
HostRabbit
IsotypeIgG
ReactivityHuman, Mouse, Rat
ConjugationUnconjugated
ApplicationWB, FCM, IHC-P, IHC-F, IF(IHC-P), IF(ICC)
Working DilutionsWB:1:500-2000 | FCM:FCM1:50-100 | IHC-P:IHC-P1:100-500 | IHC-F:IHC-F1:100-500 | IF(IHC-P):IFIHC-P1:100-500 | IF(ICC):IFICC1:50-200
ClonalityRecombinant
ConcentrationLot dependent
PurityPurified by Protein A.
Formulation0.01M TBS (pH 7.4), 1% BSA, 0.02% Proclin 300, and 50% Glycerol
StorageShipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Scientific Background

Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression.

Synonyms

E3 SUMO-protein ligase TRIM28; KRAB-associated protein 1; KAP-1; KRAB-interacting protein 1; KRIP-1; Nuclear corepressor KAP-1; KAP1; TF1B; RNF96; TIF1B; TRIM28.

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