TRXR1 Antibody#6925,Cell Signaling Technology (CST),6925

TRXR1 (thioredoxin reductase 1) is a selenocysteine-containing protein that is involved in redox homeostasis (1-6). Its canonical target is thioredoxin, another redox protein (1). Together, they are involved in many functions such as antioxidant regulation (3-6), cell proliferation (2,3,5), DNA replication (2,3), and transcription (3,5). TRXR1 is also capable of reducing a wide array of cellular proteins (1,3). Selenium deficiency, either by diet modification (2,6) or introduction of methylmercury (4), hinders proper expression and function of TRXR1. It is possible that this effect, which results in a higher oxidative state, is a result of the selenocysteine codon (UGA) being read as a STOP codon in the absence of adequate selenium (4). The functions of TRXR1 in cell proliferation and antioxidant defense make it a potential therapeutic target.Turanov, A.A. et al. (2010)Biochem J430, 285-93.Gasdaska, P.Y. et al. (1995)FEBS Lett373, 5-9.Gromer, S. et al. (2004)Med Res Rev24, 40-89.Usuki, F. et al. (2011)J Biol Chem286, 6641-9.Pappas, A.C. et al. (2008)Comp Biochem Physiol B Biochem Mol Biol151, 361-72.Müller, M. et al. (2010)Genes Nutr5, 297-307.Alternate NamesGene associated with retinoic and IFN-induced mortality 12 protein; Gene associated with retinoic and interferon-induced mortality 12 protein; GRIM-12; GRIM12; KDRF; KM-102-derived reductase-like factor; MGC9145; oxidoreductase; selenoprotein TXNRD1; testis tissue sperm-binding protein Li 46a; thioredoxin reductase 1; Thioredoxin reductase 1, cytoplasmic; thioredoxin reductase GRIM-12; Thioredoxin reductase TR1; TR; TR1; TRXR1; TXNR; TXNRD1

Gene associated with retinoic and IFN-induced mortality 12 protein; Gene associated with retinoic and interferon-induced mortality 12 protein; GRIM-12; GRIM12; KDRF; KM-102-derived reductase-like factor; MGC9145; oxidoreductase; selenoprotein TXNRD1; testis tissue sperm-binding protein Li 46a; thioredoxin reductase 1; Thioredoxin reductase 1, cytoplasmic; thioredoxin reductase GRIM-12; Thioredoxin reductase TR1; TR; TR1; TRXR1; TXNR; TXNRD1