TSPO (F5B8F) Rabbit Monoclonal Antibody#99128,Cell Signaling Technology (CST),99128

Translocator protein (TSPO) is an 18 kDa mitochondrial drug- and cholesterol-transporting protein involved in steroid hormone synthesis and mitochondrial homeostasis in various cell types (1,2). Originally thought to play a role exclusively in steroid synthesis in steroidogenic cells, subsequent research studies have implicated TSPO in a variety of pathologies in a broad range of tissues, including progression of breast cancer, neuroinflammation, and neurological disorders (1,3-5). TSPO was first identified by its ability to bind benzodiazepines in peripheral tissues and glial cells, hence its alternate name, Peripheral Benzodiazepine Receptor (PBR).TSPO has been shown to modulate an array of cellular functions; it is critical for steroidogenesis, modulates mitochondrial function and metabolism, and plays a role in both cell proliferation and apoptosis (2,6,7). TSPO is found in the outer mitochondrial membrane where it coordinates with Steroidogenic Acute Regulatory Factor (StAR) to transport cholesterol into the mitochondria and is critical for steroidogenesis and tumor progression (8,9). This is illustrated by studies that show the non-aggressive, hormone-dependent cell line, MCF7, expresses low levels of TSPO whereas the more aggressive, metastatic, and hormone-independent cell line, MDA-MB-231, expresses high levels of TSPO (9). This study, and others, suggest that TSPO may be an important regulator of hormone-dependent tumor progression. Numerous investigations have concluded that due to its high affinity for pharmacological compounds and upregulation in disease, TSPO is an attractive target for diagnosis and treatment of tumor progression, neuroinflammation, neurodegeneration, and neurological/psychiatric disorders (10-14).Batarseh, A. and Papadopoulos, V. (2010)Mol Cell Endocrinol327, 1-12.Gatliff, J. and Campanella, M. (2012)Curr Mol Med12, 356-68.Sileikyte, J. et al. (2011)J Biol Chem286, 1046-53.Mukherjee, S. and Das, S.K. (2012)Curr Mol Med12, 443-57.Da Pozzo, E. et al. (2012)Curr Mol Med12, 426-42.Riond, J. et al. (1991)Eur J Biochem195, 305-11.Veenman, L. and Gavish, M. (2012)Curr Mol Med12, 398-412.Papadopoulos, V. et al. (1997)Steroids62, 21-8.Batarseh, A. et al. (2012)Biochim Biophys Acta1819, 38-56.Scarf, A.M. and Kassiou, M. (2011)J Nucl Med52, 677-80.Rupprecht, R. et al. (2010)Nat Rev Drug Discov9, 971-88.Venneti, S. et al. (2013)Glia61, 10-23.Politis, M. et al. (2012)Front Pharmacol3, 96.Calabresi, P.A. and Bohnen, N.I. (2012)Neurology79, 496-7.Alternate Namesbenzodiazepine receptor, peripheral; Bzrp; IBP; isoquinoline-binding protein; Mbr; Mitochondrial benzodiazepine receptor; PBR; Peripheral-type benzodiazepine receptor; PKBS; Translocator protein; Tspo; Tspo1

benzodiazepine receptor, peripheral; Bzrp; IBP; isoquinoline-binding protein; Mbr; Mitochondrial benzodiazepine receptor; PBR; Peripheral-type benzodiazepine receptor; PKBS; Translocator protein; Tspo; Tspo1