Tapasin (E6P2Z) Rabbit Monoclonal Antibody (BSA and Azide Free)#37427,Cell Signaling Technology (CST),37427

TAP-associated glycoprotein (Tapasin/TAPBP) is a type-I transmembrane ER glycoprotein encoded by an MHC-linked gene. Tapasin plays a critical role in the MHC class I-restricted antigen processing and presentation pathway. Research studies have demonstrated that Tapasin is an IFNγ-inducible component of the TAP-1/2 peptide transporter complex and, within the ER lumen, facilitates the optimization of the peptide repertoire that is loaded onto MHC class I molecules (1-5). Downregulation of Tapasin and MHC class I expression has been observed in human tumors and serves as a prominent mechanism of tumor immune escape (6-9).Li, S. et al. (1997)Proc Natl Acad Sci U S A94, 8708-13.Praveen, P.V. et al. (2010)Eur J Immunol40, 214-24.Ortmann, B. et al. (1997)Science277, 1306-9.Williams, A.P. et al. (2002)Immunity16, 509-20.Garbi, N. et al. (2003)Eur J Immunol33, 264-73.Ogino, T. et al. (2003)Clin Cancer Res9, 4043-51.Cabrera, C.M. et al. (2005)Int J Cancer113, 611-8.Sokol, L. et al. (2015)J Transl Med13, 279.Jiang, Q. et al. (2010)Tumour Biol31, 451-9.Alternate NamesNGS-17; NGS17; TAP binding protein; TAP binding protein (tapasin); TAP-associated protein; TAP-binding protein; TAPA; Tapasin; TAPBP; TPN; TPSN

NGS-17; NGS17; TAP binding protein; TAP binding protein (tapasin); TAP-associated protein; TAP-binding protein; TAPA; Tapasin; TAPBP; TPN; TPSN