Thioredoxin Polyclonal Antibody,Bioss,bs-0458r

Host

Rabbit

Reactivity

Human, Mouse, Rat

Application

ELISA, IHC-P, IHC-F, IF, Flow-Cyt, ICC/IF

Conjugate

Unconjugated

Platform ID

BAB913339531

Bioss

Headquarters

300 Tradecenter Dr, ste 4610Woburn, Massachusetts 01801 - U.S.A.

Bioss

Contact

Tel: +1.781.569.5821
Fax: +1.781.731.9286

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameThioredoxin Polyclonal Antibody
Cat. No.bs-0458r
Accession NumberP10599
Gene ID (Entrez)7295
HostRabbit
IsotypeIgG
ReactivityHuman, Mouse, Rat
ConjugationUnconjugated
ApplicationELISA, IHC-P, IHC-F, IF, Flow-Cyt, ICC/IF
Working DilutionsELISA:1:1000-5000 | IHC-P:1:100-500 | IHC-F:1:100-500 | IF:1:100-500 | Flow-Cyt:1µg/Test | ICC/IF:1:100
ClonalityPolyclonal
Concentration1ug/ul
PurityPurified by Protein A.
Formulation0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
StorageShipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Scientific Background

Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity. ADF augments the expression of the interleukin-2 receptor TAC (IL2R/P55).

Synonyms

TRX; TRDX; TRX1; Thioredoxin; ATL-derived factor; ADF; Surface-associated sulphydryl protein; SASP; TXN

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