Thymidylate synthase antibody [N3C3],Genetex,GTX113289

Host

Rabbit

Reactivity

Human, Zebrafish

Application

WB

Conjugate

Unconjugated

Platform ID

BAB192964328

Genetex

Headquarters

2456 Alton Pkwy Irvine, CA 92606 USA

Genetex

Contact

Tel: 1-949-553-1900
Fax: 1-949-309-2888

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameThymidylate synthase antibody [N3C3]
Cat. No.GTX113289
Gene ID (Entrez)7298
HostRabbit
IsotypeIgG
ReactivityHuman, Zebrafish
ConjugationUnconjugated
ApplicationWB
ClonalityPolyclonal
Concentration0.53 mg/ml (Please refer to the vial label for the specific concentration.)
TargetTYMS
ImmunogenRecombinant protein encompassing a sequence within the center region of human Thymidylate synthase. The exact sequence is proprietary.
PurityPurified by antigen-affinity chromatography.
Appearance/FormLiquid
FormulationPBS, 20% Glycerol,0.025% ProClin 300
StorageStore as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Regulatory StatusResearch Use Only

Scientific Background

Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase. [provided by RefSeq]

Synonyms

thymidylate synthetase , HST422 , TMS , TS

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