TotalSeq-A0118 anti-mouse NK-1.1 Antibody anti-NK-1.1 - PK136,BioLegend,108755

Additional reported applications (for the relevant formats) include: immunoprecipitation1,2, complement-dependent cytotoxicity3,in vivodepletion4,5,9,10, mediation ofin vitroredirected lysis6, blocking of NK cell function7, induction of proliferation8, immunohistochemical staining of frozen sections11, immunofluorescence microscopy11, and spatial biology (IBEX)16,17. The LEAF™ purified antibody (Endotoxin <0.1 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. No. 108712).

Host

Mouse

Reactivity

Mouse

Application

PG -Quality tested

Platform ID

BAB079340043

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Product Specifications
Scientific Background

Specifications

NameTotalSeq-A0118 anti-mouse NK-1.1 Antibody anti-NK-1.1 - PK136
Cat. No.108755
HostMouse
RRIDAB_2750536 (BioLegend Cat. No. 108755)
IsotypeMouse IgG2a, κ
ReactivityMouse
ApplicationPG -Quality tested
ClonalityMonoclonal
Clone NumberPK136
Concentration0.5 mg/ml
TargetNK-1.1
ImmunogenNK-1+cells from mouse spleen and bone marrow
PurityThe antibody was purified by chromatography and conjugated with TotalSeq™-A oligomer under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and EDTA
StorageThe antibody solution should be stored undiluted between 2°C and 8°C.Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

NK-1.1 surface antigen, also known as CD161b/CD161c and Ly-55, is encoded by the NKR-P1B/NKR-P1C gene. It is expressed on NK cells and NK-T cells in some mouse strains, including C57BL/6, FVB/N, and NZB, but not AKR, BALB/c, CBA/J, C3H, DBA/1, DBA/2, NOD, SJL, and 129. Expression of NKR-P1C antigen has been correlated with lysis of tumor cellsin vitroand rejection of bone marrow allograftsin vivo. NK-1.1 has also been shown to play a role in NK cell activation, IFN-γ production, and cytotoxic granule release. NK-1.1 and DX5 are commonly used as mouse NK cell markers.

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