TotalSeq-A0195 anti-mouse CD134 OX-40 Antibody, CD134, OX-86,BioLegend,119426

Clone OX-86 has been reported to act as an agonist and stimulate OX-40.

Host

Rat

Reactivity

Mouse

Application

PG -Quality tested

Platform ID

BAB951079109

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Contact

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Product Specifications
Scientific Background

Specifications

NameTotalSeq-A0195 anti-mouse CD134 OX-40 Antibody, CD134, OX-86
Cat. No.119426
HostRat
RRIDAB_2750376 (BioLegend Cat. No. 119426)
IsotypeRat IgG1, κ
ReactivityMouse
ApplicationPG -Quality tested
ClonalityMonoclonal
Clone NumberOX-86
Concentration0.5 mg/ml
TargetCD134
ImmunogenRecombinant mouse OX-40-CD4 chimeric protein
PurityThe antibody was purified by chromatography and conjugated with TotalSeq™-A oligomer under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and EDTA
StorageThe antibody solution should be stored undiluted between 2°C and 8°C.Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

CD134 is a type I integral membrane protein also known as OX-40, ACT35, and tumor necrosis factor receptor superfamily member 4 (TNFRSF4). This receptor is expressed on activated CD4+and CD8+T cells and B cells. The OX-40 receptor binds to the OX-40 ligand (CD252) to provide a costimulatory signal that is independent of CD28. Blockade of OX40-OX40 ligand interactions has been shown to ameliorate experimental EAE and inflammatory bowel disease, which implies that these interactions are important in the pathogenesis of some autoimmune diseases.

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