TotalSeq-A0371 anti-human CD49b Antibody, CD49b, P1E6-C5,BioLegend,359311

Additional reported applications (for the relevant formats of this clone) include:in vitroblocking activity1,2, immunoprecipitation3, and ELISA4.

Host

Mouse

Reactivity

Human

Application

PG -Quality tested

Platform ID

BAB076541387

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Product Specifications
Scientific Background

Specifications

NameTotalSeq-A0371 anti-human CD49b Antibody, CD49b, P1E6-C5
Cat. No.359311
HostMouse
RRIDAB_2750363 (BioLegend Cat. No. 359311)
IsotypeMouse IgG1, κ
ReactivityHuman
ApplicationPG -Quality tested
ClonalityMonoclonal
Clone NumberP1E6-C5
Concentration0.5 mg/ml
TargetCD49b
ImmunogenHT1080 cells
PurityThe antibody was purified by chromatography and conjugated with TotalSeq™-A oligomer under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and EDTA
StorageThe antibody solution should be stored undiluted between 2°C and 8°C.Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

CD49b is a 170 kD transmembrane protein, also known as α2integrin, VLA-2 α chain, Integrin α2and GPIa. It associates with CD29 (β1integrin) to form VLA-2, a collagen and laminin receptor on many cell types including monocytes, platelets, activated T cells, megakaryocytes, neuronal cells, epithelial cells, and osteoclasts. CD49b has been reported to interact with F-actin and matrix metalloproteinase 1. CD49b is a platelet alloantigen and has been associated with neonatal alloimmune thrombocytopenia. Deficiencies in this protein have been associated with hemorrhagic disorders.

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