TotalSeq™-A0588 anti-human CD202b (Tie2/Tek) Antibody, CD202b, 33.1 (Ab33),BioLegend,334213

Additional reported applications include: immunoprecipitation, Wstern blot, immunohistochemical staining of frozen tissue sections and ELISA

Host

Mouse

Reactivity

Human

Application

PG -Quality tested

Platform ID

BAB743156431

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Product Specifications
Scientific Background

Specifications

NameTotalSeq™-A0588 anti-human CD202b (Tie2/Tek) Antibody, CD202b, 33.1 (Ab33)
Cat. No.334213
HostMouse
RRIDAB_2810511 (BioLegend Cat. No. 334213)
IsotypeMouse IgG1, κ
ReactivityHuman
ApplicationPG -Quality tested
ClonalityMonoclonal
Clone Number33.1 (Ab33)
Concentration0.5 mg/ml
TargetCD202b
ImmunogenRecombinant extracellular domain of human Tie2
PurityThe antibody was purified by chromatography and conjugated with TotalSeq™-A oligomer under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and EDTA
StorageThe antibody solution should be stored undiluted between 2°C and 8°C.Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

CD202b is a 145 kD type I transmembrane protein, also known as Tie2 or TEK. It is a member of the receptor tyrosine kinase (RTK) family of proteins and is expressed by endothelial cells and their progenitors, quiescent hematopoietic stem cells (HSCs), and a subpopulation of monocytes. Angiopoietin-1 (Ang-1) is an activator of CD202b to promote, maintain, and stabilize mature vessels and to maintain HSCs in quiescent state. Ang-2 is another ligand of CD202b, which is involved in postnatal angiogenesis and in antagonizing the effects of Ang-1. Tie2 binds to Ang-4 as well.

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