TotalSeq™-B0420 anti-human CD158 (KIR2DL1/S1/S3/S5) Antibody, CD158, HP-MA4,BioLegend,339521
mAb HP-MA4 reacts with KIR2DL1 (CD158a), KIR2DS1 (CD158h), KIR2DS3, and KIR2DS5 (CD158g).Additional reported applications include: inhibits NK cell mediated cytotoxicity and immunoprecipitation.This clone has been tested in-house and determined to not be suitable for applications in immunohistochemistry of paraffin-embedded tissue sections (IHC-P).
Host
Mouse
Reactivity
Human
Application
PG - Quality tested
Platform ID
BAB987272992
BioLegend
Contact
Tel: 1-858-455-9588
Fax: +49 (4131) 7023913
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Product Specifications
Scientific Background
Specifications
NameTotalSeq™-B0420 anti-human CD158 (KIR2DL1/S1/S3/S5) Antibody, CD158, HP-MA4
Cat. No.339521
HostMouse
RRIDAB_2890769 (BioLegend Cat. No. 339521)
IsotypeMouse IgG2b, κ
ReactivityHuman
ApplicationPG - Quality tested
ClonalityMonoclonal
Clone NumberHP-MA4
Concentration0.5 mg/mL
TargetCD158
ImmunogenHuman NK cell clone LB2
PurityThe antibody was purified by chromatography and conjugated with TotalSeq™-B oligomer under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and EDTA
StorageThe antibody solution should be stored undiluted between 2°C and 8°C.Do not freeze.
Regulatory StatusResearch Use Only
Scientific Background
CD158 molecules, also known as KIRs (killer cell immunoglobulin-like receptors), are a family of transmembrane proteins with either two (KIR2D) or three (KIR3D) Ig-like extracellular domains. Some KIRs with long cytoplasmic domains contain ITIMs and posses inhibitory functions and others with short cytoplasmic region lack ITIM and have activation functions. 14 polymorphic KIR genes have been reported in humans. CD158 is mainly expressed on a subset of NK cells and a small population of CD8+T cells. HLA-C is the ligand of CD158a/h.
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
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