TotalSeq™-B0842 anti-mouse Ly-49A Antibody, Ly-49A, YE1/48.10.6,BioLegend,116815

Additional reported applications (for the relevant formats) include: immunoprecipitation1,2

Host

Rat

Reactivity

Mouse

Application

PG - Quality tested

Platform ID

BAB415634866

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Contact

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Product Specifications
Scientific Background

Specifications

NameTotalSeq™-B0842 anti-mouse Ly-49A Antibody, Ly-49A, YE1/48.10.6
Cat. No.116815
HostRat
RRIDAB_2888910 (BioLegend Cat. No. 116815)
IsotypeRat IgG2a, κ
ReactivityMouse
ApplicationPG - Quality tested
ClonalityMonoclonal
Clone NumberYE1/48.10.6
Concentration0.5 mg/mL
TargetLy-49A
ImmunogenCon A activated splenic T cells
PurityThe antibody was purified by chromatography and conjugated with TotalSeq™-B oligomer under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and EDTA
StorageThe antibody solution should be stored undiluted between 2°C and 8°C.Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

Ly-49A is a 44 kD member of the C-type lectin/Ly-49 family proteins. It is a type-II transmembrane, disulfide-linked homodimer with C-type lectin extracellular domains. Ly-49A is present on a subset of NK and NK-T cells. Ly-49A, like other members of this family, inhibits NK cell activation through the recognition and interaction of certain MHC class I haplotypes on potential target cells. The Ly-49A receptor recognizes H-2Ddand H-2Dk, triggering phosphorylation of the ITIM motif in the cytoplasmic domain and recruitment of SHP-1 and SHP-2. The YE1/48.10.6 antibody reacts with NK cells from all mouse strains tested and reverses the inhibition of NK cytotoxicity.

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