TotalSeq™-B1007 anti-mouse CD85k (gp49 Receptor) Antibody, CD85k, H1.1,BioLegend,144911
Clone H1.1 recognizes both gp49A and gp49B. Additional reported applications (for the relevant formats) includein vitroactivation of gp49B to inhibit cytokine production. The LEAF™ or Ultra-LEAF™ purified antibody is recommended for functional assays (contact ourcustom solutions team).
Host
Armenian Hamster
Reactivity
Mouse
Application
PG - Quality tested
Platform ID
BAB913896965
BioLegend
Contact
Tel: 1-858-455-9588
Fax: +49 (4131) 7023913
Email:
Specifications
Scientific Background
gp49, also known as ILT3, gp49b1 or CD85k, is a 49 kD glycoprotein expressed on activated NK cells and myeloid cells. It structurally resembles killer inhibitory receptors (KIR). gp49B is a type I membrane protein belonging to the Ig superfamily and contains an immunoreceptor tyrosine-based inhibitory motif (ITIM), while gp49A is a truncated molecule without ITIM. Upon activation following interaction with integrin avb3, the cytoplasmic tail associates with SHP-1 and SHP-2, which results in downregulation of cell activation and cytokine production.
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
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