TotalSeq™-B1509 anti-human Bcl11b Antibody, Bcl11b, W17189A,BioLegend,384505

The transcription factor, Bcl11b, is expressed in the thymus, mainly T cells. It is indispensable for T lineage development. When Bcl11b was deleted, T cells from all developmental stages acquired NK cell properties and concomitantly lost or decreased T cell-associated gene expression. These induced T-to-natural killer (ITNK) cells, which were morphologically and genetically similar to conventional NK cells, killed tumor cellsin vitro, and effectively prevented tumor metastasisin vivo. Therefore, ITNKs may represent a new cell source for cell-based therapies.