TotalSeq™-C0003 anti-mouse CD366 (Tim-3) Antibody, CD366, RMT3-23,BioLegend,119739

Additional reported applications (for relevant formats) include:in vitro1andin vivo2blocking of Tim-3, and immunohistochemical staining of frozen sections2. The Ultra-LEAF™ purified antibody (Endotoxin <0.01 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. Nos. 119731-119736).

Host

Rat

Reactivity

Mouse

Application

PG -Quality tested

Platform ID

BAB836711503

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Contact

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Product Specifications
Scientific Background

Specifications

NameTotalSeq™-C0003 anti-mouse CD366 (Tim-3) Antibody, CD366, RMT3-23
Cat. No.119739
HostRat
RRIDAB_2832424 (BioLegend Cat. No. 119739)
IsotypeRat IgG2a, κ
ReactivityMouse
ApplicationPG -Quality tested
ClonalityMonoclonal
Clone NumberRMT3-23
Concentration0.5 mg/mL
TargetCD366
PurityThe antibody was purified by chromatography and conjugated with TotalSeq™-C oligomer under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and EDTA
StorageThe antibody solution should be stored undiluted between 2°C and 8°C.Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

CD366 (Tim-3) is a transmembrane protein also known as T cell immunoglobulin and mucin domain containing protein-3. Tim-3 is expressed at high levels on Th1 lymphocytes and CD11b+macrophages. Tim-3 has also been shown to exist as a soluble protein. Cells expressing Tim-3 are present at high levels in the CNS of animals at the onset of experimental autoimmune encephalomyelitis (EAE), a disease mediated by lymphocytes secreting Th1-like cytokines. Tim-3 has been proposed to inhibit Th1-mediated immune responses and promote immunological tolerance.

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