TotalSeq™-C0068 anti-human CD105, Antibody CD105, 43A3,BioLegend,323227

Host

Mouse

Reactivity

Human

Application

PG -Quality tested

Platform ID

BAB747354415

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Headquarters

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Contact

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Product Specifications
Scientific Background

Specifications

NameTotalSeq™-C0068 anti-human CD105, Antibody CD105, 43A3
Cat. No.323227
HostMouse
RRIDAB_2860847 (BioLegend Cat. No. 323227)
IsotypeMouse IgG1, κ
ReactivityHuman
ApplicationPG -Quality tested
ClonalityMonoclonal
Clone Number43A3
Concentration0.5 mg/mL
TargetCD105
ImmunogenL-cells transfected with human CD105
PurityThe antibody was purified by chromatography and conjugated with TotalSeq™-C oligomer under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and EDTA
StorageThe antibody solution should be stored undiluted between 2°C and 8°C.Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

CD105 is also known as Endoglin. It is a type I integral membrane homodimer protein with subunits of 90 kD found on vascular endothelial cells and syncytiotrophoblasts of placenta. CD105 is weakly expressed on stromal fibroblasts. It is also expressed on activated monocytes and tissue macrophages. Expression of CD105 is increased on activated endothelium in tissues undergoing angiogenesis, such as in tumors, or in cases of wound healing or dermal inflammation. CD105 is a component of the TGF-β receptor system in human umbilical vein endothelial cells and binds TGF-β1 and β3 with high affinity but does not bind to TGF-β2.

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