TotalSeq™-C0217 anti-human CD54 Antibody, CD54, HA58,BioLegend,353127

Clone HA58 recognizes an epitope located in the extracellular D1 domain of CD543. Additional reported applications (for the relevant formats) include: spatial biology (IBEX)4,5.

Host

Mouse

Reactivity

Human

Application

PG -Quality tested

Platform ID

BAB916095909

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Product Specifications
Scientific Background

Specifications

NameTotalSeq™-C0217 anti-human CD54 Antibody, CD54, HA58
Cat. No.353127
HostMouse
RRIDAB_2810562 (BioLegend Cat. No. 353127)
IsotypeMouse IgG1, κ
ReactivityHuman
ApplicationPG -Quality tested
ClonalityMonoclonal
Clone NumberHA58
Concentration0.5 mg/ml
TargetCD54
ImmunogenColonic cancer BM314 cells
PurityThe antibody was purified by chromatography and conjugated with TotalSeq™-C oligomer under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and EDTA
StorageThe antibody solution should be stored undiluted between 2°C and 8°C.Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

CD54 is a 85-110 kD type I transmembrane protein also known as ICAM-1. It is expressed on activated endothelial cells, high endothelial venules, T and B cells, monocytes/macrophages, granulocytes, and dendritic cells. The expression of ICAM-1 can be released from the cell surface. CD54 plays a role in cellular adhesion and is involved in inflammation and leukocyte extravasation. CD54 has also been shown to be the major cellular receptor for rhinovirus. ICAM-1 binds to CD11a/CD18 (LFA-1), CD11b/CD18 (Mac-1), CD11c/CD18 (p150, 95) as well as hyaluronan and fibrinogen.

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