TotalSeq™-C0246 anti-human CD122 (IL-2Rβ) Antibody, CD122, TU27,BioLegend,339021

Additional reported applications include (for the relevant formats) include: immunoprecipitation, blocking of IL-2 binding to CD122, and partial inhibition of IL-2 induced cell proliferation.

Host

Mouse

Reactivity

Human

Application

PG -Quality tested

Platform ID

BAB346656727

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Contact

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Product Specifications
Scientific Background

Specifications

NameTotalSeq™-C0246 anti-human CD122 (IL-2Rβ) Antibody, CD122, TU27
Cat. No.339021
HostMouse
RRIDAB_2814240 (BioLegend Cat. No. 339021)
IsotypeMouse IgG1, κ
ReactivityHuman
ApplicationPG -Quality tested
ClonalityMonoclonal
Clone NumberTU27
Concentration0.5 mg/ml
TargetCD122
ImmunogenTL-Mor cell line
PurityThe antibody was purified by chromatography and conjugated with TotalSeq™-C oligomer under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and EDTA
StorageThe antibody solution should be stored undiluted between 2°C and 8°C.Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

CD122 is a 70-75 kD type I transmembrane glycoprotein and member of the Ig superfamily. It is IL-2 receptor β chain also known as IL-2Rβ, which is also shared by the IL-15 receptor. CD122 is constitutively expressed by NK cells and at lower levels by a subset of T cells. Its expression is upregulated upon activation. The IL-2Rβ chain can combine with either the common γ subunit (γc, CD132) alone or with the γc subunit and the IL-2Rα subunit (CD25) to generate intermediate or high affinity IL-2 receptor complexes, respectively. CD122 expression levels can be upregulated by activation.

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