TotalSeq™-C0400 anti-human CD144 VE-Cadherin Antibody, CD144, BV9,BioLegend,348521

Clone BV9 has been shown to block VE-cadherin, causing a redistribution of VE-cadherin away from intracellular junctions.6This clone binds to EC3-EC4 region in the extracellular domain of human VE-cadherin.7Additional reported applications (for the relevant formats) include: Western Blotting1,2, immunofluorescence microscopy1,3, immunoprecipitation1,4, blocking angiogenesisin vitro4,5, inhibiting VE-cadherin reorganization4, and inducing endothelial cell apoptosis4.

Host

Mouse

Reactivity

Human

Application

PG -Quality tested

Platform ID

BAB024766251

BioLegend

Headquarters

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BioLegend

Contact

Tel: 1-858-455-9588
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Product Specifications
Scientific Background

Specifications

NameTotalSeq™-C0400 anti-human CD144 VE-Cadherin Antibody, CD144, BV9
Cat. No.348521
HostMouse
RRIDAB_2832677 (BioLegend Cat. No. 348521)
IsotypeMouse IgG2a, κ
ReactivityHuman
ApplicationPG -Quality tested
ClonalityMonoclonal
Clone NumberBV9
Concentration0.5 mg/mL
TargetCD144
PurityThe antibody was purified by chromatography and conjugated with TotalSeq™-C oligomer under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and EDTA
StorageThe antibody solution should be stored undiluted between 2°C and 8°C.Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

CD144, also known as VE-cadherin and cadherin-5, is a 140 kD glycoprotein which is composed of five extracellular cadherin repeats and a highly conserved cytoplasmic tail region. It is a calcium-dependent transmembrane cell-cell adhesion molecule localized at the intercellular boundaries of endothelial cells, hematopoietic stem cells, and perineurial cells. It functions as a classic cadherin by mediating homophilic adhesion and functions as a plasma membrane attachment site for the cytoskeleton. CD144 is thought to play a role in vascular development, permeability, and remodeling.

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