TotalSeq™-C0839 anti-mouse Ly49H Antibody, Ly49H, 3D10,BioLegend,144719

Additional reported applications (for the relevant formats of this clone) include: immunoprecipation1, andin vitro2andin vivo3blocking activity. The Ultra-LEAF™ purified antibody (Endotoxin < 0.01 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. No. 144717 & 144718).

Host

Mouse

Reactivity

Mouse

Application

PG -Quality tested

Platform ID

BAB995180459

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Contact

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Product Specifications
Scientific Background

Specifications

NameTotalSeq™-C0839 anti-mouse Ly49H Antibody, Ly49H, 3D10
Cat. No.144719
HostMouse
RRIDAB_2876494 (BioLegend Cat. No. 144719)
IsotypeMouse IgG1, κ
ReactivityMouse
ApplicationPG -Quality tested
ClonalityMonoclonal
Clone Number3D10
Concentration0.5 mg/mL
TargetLy49H
ImmunogenC1498-Ly49A/H transfectant
PurityThe antibody was purified by chromatography and conjugated with TotalSeq™-C oligomer under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and EDTA
StorageThe antibody solution should be stored undiluted between 2°C and 8°C.Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

Ly49H, also known as Cmv1 and Klra8, is a 28.3 kD protein.  It is expressed on NK cells (but not on NKT cells) from C57BL/6 mice (but not Balb/c or DBA/2 mice).  Expression of Ly49H has been associated with resistance to MCMV infection in C57BL/6 mice.  Modulation of Ly49H expression by its antibody made MCMV-resistant C57BL/6 mice susceptible to infection.  Unlike Ly49A, Ly49H lacks the ITIM (immunoreceptor tyrosine-based inhibitory motif) but has ITAM (immunoreceptor tyrosine-based activation motif), which is associated with DAP-12 (KARAP, killer cell activating motif).

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