TotalSeq™-C0874 anti-human/mouse/rat MR1 Antibody, MR1, 26.5,BioLegend,361113
Additional reported applications for the relevant formats include: blocking MR1-dependent activation of MAIT hybridomas, clones, or MAIT TCR-transduced cell lines1-6, detection of folded MR1 conformers3,7, and immunoprecipitation of MR1 from cell lysates7.
Host
Mouse
Reactivity
Human, Mouse, Rat
Application
PG - Quality tested
Platform ID
BAB986184779
BioLegend
Contact
Tel: 1-858-455-9588
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Product Specifications
Scientific Background
Specifications
NameTotalSeq™-C0874 anti-human/mouse/rat MR1 Antibody, MR1, 26.5
Cat. No.361113
HostMouse
RRIDAB_2927966 (BioLegend Cat. No. 361113)
IsotypeMouse IgG2a, κ
ReactivityHuman, Mouse, Rat
ApplicationPG - Quality tested
ClonalityMonoclonal
Clone Number26.5
Concentration0.5 mg/mL
TargetMR1
ImmunogenSoluble complexes of MR1 ectodomain and B2M.
PurityThe antibody was purified by chromatography and conjugated with TotalSeq™-C oligomer under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and EDTA
StorageThe antibody solution should be stored undiluted between 2°C and 8°C.Do not freeze.
Regulatory StatusResearch Use Only
Scientific Background
MHC-related protein 1, also known as MR1, is a nonclassical MHC class I molecule highly conserved in mammals, particularly in its α1/α2 domains. MR1 is required for the development and expansion of the mucosal-associated invariant T (MAIT) cells. The transcripts for MR1 are ubiquitously expressed, but its expression on the cell surface seems to be ligand-dependent. MR1 is involved in the presentation of vitamin-derived compounds from bacterial biosynthetic pathways.
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
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