TotalSeq™-C1028 anti-mouse CD104 Antibody, CD104, 346-11A,BioLegend,123617

Additional reported (for the relevant formats) applications include: immunohistochemical staining1.

Host

Rat

Reactivity

Mouse

Application

PG -Quality tested

Platform ID

BAB181025004

BioLegend

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Contact

Tel: 1-858-455-9588
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Product Specifications
Scientific Background

Specifications

NameTotalSeq™-C1028 anti-mouse CD104 Antibody, CD104, 346-11A
Cat. No.123617
HostRat
RRIDAB_2876443 (BioLegend Cat. No. 123617)
IsotypeRat IgG2a, κ
ReactivityMouse
ApplicationPG -Quality tested
ClonalityMonoclonal
Clone Number346-11A
Concentration0.5 mg/mL
TargetCD104
ImmunogenTumor-associated antigen TSP-180 from BALB/c lung carcinoma
PurityThe antibody was purified by chromatography and conjugated with TotalSeq™-C oligomer under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and EDTA
StorageThe antibody solution should be stored undiluted between 2°C and 8°C.Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

CD104 is a 205 kD type I transmembrane glycoprotein, also known as integrin β4 chain or β4 integrin, that associates with integrin α6 (CD49f) to form the α6/β4 (CD49f/CD104) heterodimer. CD104 is expressed on epithelial cells (especially on proliferative basal layer epithelial cells in skin), endothelial cells, Schwann cells, certain tumor cells, and a subset of pre-T cells. The CD49f/CD104 heterodimer is an adhesion receptor for laminins (especially laminin 5) and keratin filaments, and is involved in the regulation of hemidesmosome formation and cell proliferation and activation.

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