TotalSeq™-D0064 anti-human CD123 antibody, CD123, 6H6,BioLegend,306051
Clone 6H6 does not inhibit IL-3 binding to low- or high-affinity IL-3Rs. Additional reported applications (for the relevant formats) include: Western blotting1, immunoprecipitation1, and immunohistochemical staining of acetone-fixed frozen sections2and also paraformaldehyde fixed paraffin embedded tissue7.
Host
Mouse
Reactivity
Human
Application
PG - Quality tested
Platform ID
BAB508424099
BioLegend
Contact
Tel: 1-858-455-9588
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Product Specifications
Scientific Background
Specifications
NameTotalSeq™-D0064 anti-human CD123 antibody, CD123, 6H6
Cat. No.306051
HostMouse
RRIDAB_2892367 (BioLegend Cat. No. 306051)
IsotypeMouse IgG1, κ
ReactivityHuman
ApplicationPG - Quality tested
ClonalityMonoclonal
Clone Number6H6
Concentration0.5 mg/mL
TargetCD123
ImmunogenHuman IL-3Rα transfected COS cells.
PurityThe antibody was purified by chromatography and conjugated with TotalSeq™-D oligomer under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and EDTA
StorageThe antibody solution should be stored undiluted between 2°C and 8°C.Do not freeze.
Regulatory StatusResearch Use Only
Scientific Background
CD123 is the 70 kD transmembrane α chain of the IL-3 receptor. Alone, CD123 binds IL-3 with low affinity; when CD123 associates with CD131 (common β chain), it binds IL-3 with high affinity. CD123 does not transduce intracellular signals upon binding IL-3 and requires the β chain for this function. CD123 is expressed by myeloid precursors, macrophages, dendritic cells, mast cells, basophils, megakaryocytes, and some B cells.
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
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