TotalSeq™-D0142 anti-human CD32 Antibody, CD32, FUN-2,BioLegend,303235

Additional reported applications (for the relevant formats) include: immunohistochemical staining3of acetone-fixed frozen tissue sections.Clone FUN-2 recognizes both CD32A and CD32B.

Host

Mouse

Reactivity

Human

Application

PG - Quality tested

Platform ID

BAB661173273

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Product Specifications
Scientific Background

Specifications

NameTotalSeq™-D0142 anti-human CD32 Antibody, CD32, FUN-2
Cat. No.303235
HostMouse
RRIDAB_2936569 (BioLegend Cat. No. 303235)
IsotypeMouse IgG2b, κ
ReactivityHuman
ApplicationPG - Quality tested
ClonalityMonoclonal
Clone NumberFUN-2
Concentration0.5 mg/mL
TargetCD32
PurityThe antibody was purified by chromatography and conjugated with TotalSeq™-D oligomer under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and EDTA
StorageThe antibody solution should be stored undiluted between 2°C and 8°C.Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

CD32 is a 40 kD polymorphic transmembrane glycoprotein also known as FcγRII and FCRII. It is an immunoglobulin superfamily member expressed on monocytes/macrophages, granulocytes, platelets and B cells. There are at least 6 isoforms of CD32 resulting from alternative mRNA splicing. CD32 mediates phagocytosis and oxidative burst in granulocytes, as well as platelet aggregation and immunomodulation. The extracellular domain of CD32 binds to polymeric and aggregated IgG and immune complexes, while the intracellular domain has been reported to associate with SHP-1 (B1 isoform).

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