TotalSeq™-D0160 anti-human CD1c antibody, CD1c, L161,BioLegend,331551

Additional reported applications (for the relevant formats) include: immunohistochemical staining on frozen tissue4, 5, formalin-fixed paraffin-embedded immunohistochemical staining6, and spatial biology (IBEX)7,8.

Host

Mouse

Reactivity

Human

Application

PG - Quality tested

Platform ID

BAB180813841

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Contact

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Product Specifications
Scientific Background

Specifications

NameTotalSeq™-D0160 anti-human CD1c antibody, CD1c, L161
Cat. No.331551
HostMouse
RRIDAB_2892400 (BioLegend Cat. No. 331551)
IsotypeMouse IgG1, κ
ReactivityHuman
ApplicationPG - Quality tested
ClonalityMonoclonal
Clone NumberL161
Concentration0.5 mg/mL
TargetCD1c
PurityThe antibody was purified by chromatography and conjugated with TotalSeq™-D oligomer under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and EDTA
StorageThe antibody solution should be stored undiluted between 2°C and 8°C.Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

CD1c, also known as R7 or M241, is a 43 kD member of the five CD1 antigens (CD1a-e) in humans. The CD1 molecules are type I glycoprotein with structural similarities to MHC class I and are non-covalently associated with β2-microglobulin, belonging to the Ig superfamily. CD1c is expressed on cortical thymocytes, Langerhans cells, dendritic cells, and a subset of B cells. It has been reported that CD1c is also expressed on mature T cells in a tightly regulated manner. CD1c is involved in antigen-presentation of glycolipids. It may also act in T cells as an immune regulatory molecule.

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