TotalSeq™-D0162 anti-human CD64 antibody, CD64, 10.1,BioLegend,305051
Clone 10.1 recognizes the EC3 epitope of CD64. While both contain the EC3 domain, in-house testing suggests that clone 10.1 preferentially binds to CD64A (FcγRIA), but not CD64B (FcγRIB). Additional reported applications (for the relevant formats) include: blocking of human IgG3 and murine IgG2a binding to FcγRI2,5,6,11and immunohistochemical staining of acetone-fixed frozen tissue sections12.
Host
Mouse
Reactivity
Human, Cynomolgus, Rhesus
Application
PG - Quality tested
Platform ID
BAB536321966
BioLegend
Contact
Tel: 1-858-455-9588
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Product Specifications
Scientific Background
Specifications
NameTotalSeq™-D0162 anti-human CD64 antibody, CD64, 10.1
Cat. No.305051
HostMouse
RRIDAB_2892360 (BioLegend Cat. No. 305051)
IsotypeMouse IgG1, κ
ReactivityHuman, Cynomolgus, Rhesus
ApplicationPG - Quality tested
ClonalityMonoclonal
Clone Number10.1
Concentration0.5 mg/mL
TargetCD64
ImmunogenHuman rheumatoid synovial fluid cells and fibronectin-purified monocytes.
PurityThe antibody was purified by chromatography and conjugated with TotalSeq™-D oligomer under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and EDTA
StorageThe antibody solution should be stored undiluted between 2°C and 8°C.Do not freeze.
Regulatory StatusResearch Use Only
Scientific Background
CD64 is a 72 kD single chain type I glycoprotein also known as FcγRI and FcR I. CD64 is a member of the immunoglobulin superfamily and is expressed on monocytes/macrophages, dendritic cells, and activated granulocytes. The expression can be upregulated by IFN-γ stimulation. CD64 binds IgG immune complex. It plays a role in antigen capture, phagocytosis of IgG/antigen complexes, and antibody-dependent cellular cytotoxicity (ADCC).
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
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