TotalSeq™-D1260 anti-human CD117 (c-kit), CD117, A3C6E2,BioLegend,323419

Additional reported applications (for the relevant formats) include: Blocking the binding of SCF. The Ultra-LEAF™ purified antibody (Endotoxin < 0.01 EU/μg, Azide-Free, 0.2 μm filtered) is recommended for functional assays (Cat. No. 323417 & 323418).

Host

Mouse

Reactivity

Human

Application

PG - Quality tested

Platform ID

BAB827827034

BioLegend

Headquarters

8999 BioLegend Way San Diego, CA 92121 United States

BioLegend

Contact

Tel: 1-858-455-9588
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Product Specifications
Scientific Background

Specifications

NameTotalSeq™-D1260 anti-human CD117 (c-kit), CD117, A3C6E2
Cat. No.323419
HostMouse
RRIDAB_2936572 (BioLegend Cat. No. 323419)
IsotypeMouse IgG1, κ
ReactivityHuman
ApplicationPG - Quality tested
ClonalityMonoclonal
Clone NumberA3C6E2
Concentration0.5 mg/mL
TargetCD117
ImmunogenMOLM-1 megakaryocitic cell line
PurityThe antibody was purified by chromatography and conjugated with TotalSeq™-D oligomer under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and EDTA
StorageThe antibody solution should be stored undiluted between 2°C and 8°C.Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

CD117 is a 145 kD protein tyrosine kinase also known as c-kit. It is a receptor for stem cell factor or c-kit ligand. CD117 is expressed on pluripotent hematopoietic progenitor cells (approximately 1-4% bone marrow cells), mast cells, and acute myeloid leukemic cells (AML). CD117 binding of c-kit ligand induces phosphorylation of CD117, and stimulates proliferation and survival of primitive hematopoietic stem cells as well as erythroid-committed and granulo-monocytic committed cells. The A3C6E2 antibody potently blocks the binding of SCF.

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