Tryptase (E7M2U) Rabbit Monoclonal Antibody#19523,Cell Signaling Technology (CST),19523

Tryptase is the most abundant neutral serine protease expressed in the secretory granules of all human mast cells (1). Tryptase is secreted upon the coupled activation-degranulation response of mast cells in peripheral tissues to physical factors such as trauma, toxins, venoms, endogenous mediators, and immune mechanisms (IgE-dependent and IgE-independent) (2). Tryptase has distinct enzymatic functions that depend on the monomeric or homotetrameric state of this protein, the pH of the environment, and the presence or absence of heparin (3-5). Tryptase has the ability to cleave extracellular substrates such as vasoactive intestinal peptides (6), calcitonin gene-related peptides (7), fibronectins (8), fibrinogens (3), and kininogens (9). Tryptase is also a potent growth factor for epithelial cells, airway smooth muscle cells, and fibroblasts (10-13).Vanderslice, P. et al. (1990)Proc Natl Acad Sci U S A87, 3811-5.Krishnaswamy, G. et al. (2001)Front Biosci6, D1109-27.Fukuoka, Y. and Schwartz, L.B. (2007)Int Immunopharmacol7, 1900-8.Ren, S. et al. (1998)J Immunol160, 4561-9.Sakai, K. et al. (1996)J Clin Invest97, 988-95.Tam, E.K. and Caughey, G.H. (1990)Am J Respir Cell Mol Biol3, 27-32.Walls, A.F. et al. (1992)Biochem Pharmacol43, 1243-8.Lohi, J. et al. (1992)J Cell Biochem50, 337-49.Walls, A.F. et al. (1992)Biochem Soc Trans20, 260S.Cairns, J.A. and Walls, A.F. (1996)J Immunol156, 275-83.Ruoss, S.J. et al. (1991)J Clin Invest88, 493-9.Brown, J.K. et al. (1995)Am J Respir Cell Mol Biol13, 227-36.Gruber, B.L. et al. (1997)J Immunol158, 2310-7.Alternate Namesepididymis secretory sperm binding protein; mast cell alpha II tryptase; mast cell beta I tryptase; TPS1; TPS2; TPSAB1; TPSB1; TPSB2; TRYA1; TRYB1; tryptase alpha II; Tryptase alpha-1; tryptase alpha/beta 1; Tryptase alpha/beta-1; tryptase beta 1; tryptase beta I; tryptase beta-1; Tryptase beta-2; tryptase I; Tryptase II; Tryptase-1; Tryptase-2; tryptase-I; tryptase-III

epididymis secretory sperm binding protein; mast cell alpha II tryptase; mast cell beta I tryptase; TPS1; TPS2; TPSAB1; TPSB1; TPSB2; TRYA1; TRYB1; tryptase alpha II; Tryptase alpha-1; tryptase alpha/beta 1; Tryptase alpha/beta-1; tryptase beta 1; tryptase beta I; tryptase beta-1; Tryptase beta-2; tryptase I; Tryptase II; Tryptase-1; Tryptase-2; tryptase-I; tryptase-III