Tyrosine Hydroxylase Antibody (YA5767),MedChemexpress,HY-P86075

Tyrosine Hydroxylase Antibody (YA5767) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Tyrosine Hydroxylase.

Host

Rabbit

Reactivity

Human,Mouse,Rat

Application

WB,IHC-P,ICC/IF,IP,ELISA

Conjugate

Non-conjugated

Platform ID

BAB598507506

Master of Bioactive Molecules

MedChemexpress

Master of Bioactive Molecules

Headquarters

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Contact

Tel: 609-228-6898
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Product Specifications
Scientific Background
Synonyms

Specifications

NameTyrosine Hydroxylase Antibody (YA5767)
Cat. No.HY-P86075
Accession NumberP07101
Gene ID (Entrez)7054
HostRabbit
IsotypeIgG
ReactivityHuman,Mouse,Rat
ConjugationNon-conjugated
ApplicationWB,IHC-P,ICC/IF,IP,ELISA
Working DilutionsIHC-P: 1:500-1:2000; WB: 1:2000-1:10000; ICC/IF: 1:200-1:1000; ELISA: 1:5000-1:20000; IP: 1:50-1:200
ClonalityMonoclonal
Clone NumberYA5767
Molecular WeightPredicted band size: 59 kDa; Observed band size: 59 kDa
PurityProtein A
Appearance/FormLiquid
ShippingShipping with blue ice.
FormulationSupplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
StorageStored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Regulatory StatusResearch Use Only

Scientific Background

Tyrosine hydroxylase is an enzyme that plays a pivotal role in the biosynthesis of catecholamines, including dopamine, noradrenaline, and adrenaline. It catalyzes the rate-limiting step in this pathway, converting L-tyrosine to L-dihydroxyphenylalanine (L-Dopa) through the use of tetrahydrobiopterin and molecular oxygen. While its primary substrate is tyrosine, tyrosine hydroxylase also exhibits lower specificity and can hydroxylate phenylalanine and tryptophan. This enzymatic activity is essential for the synthesis of neurotransmitters involved in various physiological processes. Moreover, tyrosine hydroxylase has been found to positively regulate the regression of retinal hyaloid vessels during postnatal development, indicating its diverse roles beyond catecholamine biosynthesis.

Synonyms

Tyrosine 3-monooxygenase; Tyrosine 3-hydroxylase; TH;

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