UBE2N/Ubc13 (D2A1) Rabbit Monoclonal Antibody#6999,Cell Signaling Technology (CST),6999

Protein ubiquitination is an important posttranslational modification that regulates protein function and fate (1). Ubiquitin (Ub) can be conjugated to target proteins in either monomeric or polymeric forms. There are several different lysine residues within Ub that can be used as conjugation sites for poly-Ub chain formation. Different poly-Ub linkages mediate different functions of the target protein ranging from alterations in protein function to degradation (2). UBE2N/Ubc13 is a ubiquitin-E2-conjugating enzyme that catalyzes K63-linked poly-Ub chain formation (1,2). UBE2N forms a heterodimer with MMS2 or Uev1A to exert its E2 ligase function. The UBE2N/MMS2 and UBE2N/Uev1A heterodimers catalyze different modes of target protein ubiquitination to mediate various signaling pathways (3-5) including: DNA damage and recombination, p53 and check point control, the cell cycle (6-10), immunoreceptor signaling (11,12), and endocytosis (13). Most recently, UBE2N was shown to play an important role in inflammatory signaling by promoting K63-linked ubiquitination and activation of IKK downstream of the IL-1β receptor (14). Furthermore, interaction of UBE2N with the Triad1 E3 protein-ubiquitin ligase was shown to play an important role in myelopoiesis (15).Herrmann, J. et al. (2007)Circ Res100, 1276-91.Wilkinson, K.D. et al. (2005)EMBO Rep6, 815-20.Hofmann, R.M. and Pickart, C.M. (1999)Cell96, 645-53.Deng, L. et al. (2000)Cell103, 351-61.Andersen, P.L. et al. (2005)J Cell Biol170, 745-55.Zhao, G.Y. et al. (2007)Mol Cell25, 663-75.Kolas, N.K. et al. (2007)Science318, 1637-40.Laine, A. et al. (2006)Mol Cell Biol26, 8901-13.Huen, M.S. et al. (2008)Mol Cell Biol28, 6104-12.Loring, G.L. et al. (2008)Cell Cycle7, 96-105.Yamamoto, M. et al. (2006)Nat Immunol7, 962-70.Yamamoto, M. et al. (2006)J Immunol177, 7520-4.Duncan, L.M. et al. (2006)EMBO J25, 1635-45.Xu, M. et al. (2009)Mol Cell36, 302-14.Marteijn, J.A. et al. (2009)Leukemia23, 1480-9.Alternate Namesbendless-like ubiquitin conjugating enzyme; Bendless-like ubiquitin-conjugating enzyme; BLU; E2 ubiquitin-conjugating enzyme N; epididymis secretory protein Li 71; HEL-S-71; MGC131857; MGC8489; Ubc13; UbcH-ben; UbcH13; UBCHBEN; UBE2N; Ubiquitin carrier protein N; ubiquitin conjugating enzyme E2 N; ubiquitin conjugating enzyme E2N; Ubiquitin-conjugating enzyme E2 N; ubiquitin-conjugating enzyme E2N (homologous to yeast UBC13); ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast); Ubiquitin-protein ligase N; yeast UBC13 homolog

bendless-like ubiquitin conjugating enzyme; Bendless-like ubiquitin-conjugating enzyme; BLU; E2 ubiquitin-conjugating enzyme N; epididymis secretory protein Li 71; HEL-S-71; MGC131857; MGC8489; Ubc13; UbcH-ben; UbcH13; UBCHBEN; UBE2N; Ubiquitin carrier protein N; ubiquitin conjugating enzyme E2 N; ubiquitin conjugating enzyme E2N; Ubiquitin-conjugating enzyme E2 N; ubiquitin-conjugating enzyme E2N (homologous to yeast UBC13); ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast); Ubiquitin-protein ligase N; yeast UBC13 homolog