UBE3C (F2S2J) Rabbit Monoclonal Antibody#32920,Cell Signaling Technology (CST),32920

UBE3C (F2S2J) Rabbit Monoclonal Antibody recognizes endogenous levels of total UBE3C protein. Reactivity for immunofluorescence is human only.

Host

Rabbit

Reactivity

Human, Mouse, Rat

Application

Western Blotting: 1:1000 Simple WesternTM: 1:10 - 1:50 Immunoprecipitation: 1:100 Immunofluorescence (Immunocytochemistry): 1:50 - 1:200

Platform ID

BAB825571795

Cell Signaling Technology (CST)

Headquarters

3 Trask Lane Danvers, MA 01923

Cell Signaling Technology (CST)

Contact

Tel: 877-616-2355,978-867-2388
Fax: 877-616-2355

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameUBE3C (F2S2J) Rabbit Monoclonal Antibody#32920
Cat. No.32920
Accession NumberQ15386
Gene ID (Entrez)15386, 9690
HostRabbit
SensitivityEndogenous
ReactivityHuman, Mouse, Rat
ApplicationWestern Blotting: 1:1000 Simple WesternTM: 1:10 - 1:50 Immunoprecipitation: 1:100 Immunofluorescence (Immunocytochemistry): 1:50 - 1:200
Molecular Weight123
ImmunogenIgG
FormulationSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C.Do not aliquot the antibody.
StorageSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C.Do not aliquot the antibody.
Regulatory StatusResearch Use Only

Scientific Background

Ubiquitin-Protein Ligase E3C (UBE3C) is an E3 ubiquitin-protein ligase that contributes to the regulation of multiple cellular processes through ubiquitination of various protein substrates, targeting them for proteasomal degradation. UBE3C activates the Wnt/β-catenin pathway, promoting proliferation and inhibiting apoptosis in cancer cells (1,2). UBE3C-mediated protein degradation also regulates autophagy signaling (3,4), viral replication (5), type I interferon signaling (6), and radioresistance (7). In addition, UBE3C participates in eliminating misfolded protein aggregates by targeting misfolded proteins for degradation (8).Zhang, Y. et al. (2021)Carcinogenesis42, 285-293.Hang, C. et al. (2021)Cancer Cell Int21, 25.Chen, Y.H. et al. (2021)Nat Commun12, 1322.Sun, C. et al. (2024)Autophagy20, 645-658.Cui, B. et al. (2024)J Virol98, e0133524.Yu, Y. and Hayward, G.S. (2010)Immunity33, 863-77.Wang, Y. et al. (2023)J Transl Med21, 321.Hickey, K.L. et al. (2024)Proc Natl Acad Sci USA121, e2417390121.Alternate NamesHECT-type ubiquitin transferase E3C; HectH2; KIAA0010; KIAA10; UBE3C; ubiquitin protein ligase E3C; ubiquitin-protein isopeptide ligase (E3); Ubiquitin-protein ligase E3C

Synonyms

HECT-type ubiquitin transferase E3C; HectH2; KIAA0010; KIAA10; UBE3C; ubiquitin protein ligase E3C; ubiquitin-protein isopeptide ligase (E3); Ubiquitin-protein ligase E3C

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