UPP1 (E6Y2B) Rabbit Monoclonal Antibody#88630,Cell Signaling Technology (CST),88630

Uridine phosphorylases (UPP1, UPP2) are metabolic enzymes that catalyze the reversible phosphorolytic cleavage of uridine into uracil and ribose-1-phosphate, which can subsequently serve as cellular energy sources or as substrates forde novonucleotide biosynthesis via pyrimidine salvage pathways (1). Altered pyrimidine metabolism has been reported in multiple cancer subtypes (2-5) and is hypothesized to be associated with cellular metabolic reprogramming events that enable enhanced tumor growth and metastasis (6,7). Notably, UPP1 was identified as one of the enzymes involved in the metabolic activation of the anti-neoplastic agent 5-fluorouracil (5-FU) (8,9). Somewhat paradoxically, numerous UPP1 inhibitors have been developed to reduce the adverse side effects of 5-FU treatment by elevating physiological levels of uridine during 5-FU administration (10).Pizzorno, G. et al. (2002)Biochim Biophys Acta1587, 133-44.Sun, C. et al. (2019)Proc Natl Acad Sci USA116, 52-57.Wang, J. et al. (2020)Cancer Med9, 5940-5947.Yan, R. et al. (2006)Front Biosci11, 2759-66.Liu, M. et al. (1998)Cancer Res58, 5418-24.Lyssiotis, C.A. and Nagrath, D. (2019)Cancers (Basel)12, 90.Wu, Z. et al. (2021)Cancer Cell Int21, 668.Higley, B. et al. (1982)Gut23, 1072-6.Renck, D. et al. (2010)Arch Biochem Biophys497, 35-42.Darnowski, J.W. and Handschumacher, R.E. (1985)Cancer Res45, 5364-8.Alternate NamesUDRPASE; UP; UPASE; UPase 1; UPP; UPP1; UrdPase 1; Uridine phosphorylase 1

UDRPASE; UP; UPASE; UPase 1; UPP; UPP1; UrdPase 1; Uridine phosphorylase 1