USP18 Rabbit pAb- ABclonal,ABclonal,A16739

Reactivity

Human, Mouse, Rat

Application

WB, IHC-P, IF/ICC, ELISA

Platform ID

BAB869584452

ABclonal

Headquarters

500W Cummings Park, Ste. 6500 Woburn, MA 01801

ABclonal

Contact

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Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameUSP18 Rabbit pAb- ABclonal
Cat. No.A16739
Accession NumberQ9UMW8
Gene ID (Entrez)11274
RRIDAB_2772822
IsotypeIgG
ReactivityHuman, Mouse, Rat
ApplicationWB, IHC-P, IF/ICC, ELISA
Working DilutionsWB:1:1000 - 1:5000 | IHC-P:1:50 - 1:200 | IF/ICC:1:50 - 1:200 | ELISA:Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Molecular Weight34kDa
ImmunogenSynthetic peptide. This information is considered to be commercially sensitive.
PurityAffinity purification
Appearance/FormLiquid
StorageStore at -20℃. Avoid freeze / thaw cycles.; Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
Regulatory StatusResearch Use Only

Scientific Background

The protein encoded by this gene belongs to the ubiquitin-specific proteases (UBP) family of enzymes that cleave ubiquitin from ubiquitinated protein substrates. It is highly expressed in liver and thymus, and is localized to the nucleus. This protein efficiently cleaves only ISG15 (a ubiquitin-like protein) fusions, and deletion of this gene in mice results in a massive increase of ISG15 conjugates in tissues, indicating that this protein is a major ISG15-specific protease. Mice lacking this gene are also hypersensitive to interferon, suggesting a function of this protein in downregulating interferon responses, independent of its isopeptidase activity towards ISG15.

Synonyms

ISG43; UBP43; PTORCH2; USP18

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