USP5 antibody [2H5],Genetex,GTX83430

Host

Mouse

Reactivity

Human, Rat, Dog, Monkey

Application

WB IHC-P

Conjugate

Unconjugated

Platform ID

BAB255711666

Genetex

Headquarters

2456 Alton Pkwy Irvine, CA 92606 USA

Genetex

Contact

Tel: 1-949-553-1900
Fax: 1-949-309-2888

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameUSP5 antibody [2H5]
Cat. No.GTX83430
Gene ID (Entrez)8078
HostMouse
IsotypeIgG2a
ReactivityHuman, Rat, Dog, Monkey
ConjugationUnconjugated
ApplicationWB IHC-P
ClonalityMonoclonal
Concentration0.99 mg/ml (Please refer to the vial label for the specific concentration.)
ImmunogenFull length human recombinant protein of human USP5 (NP_003472) produced in HEK293T cell.
PurityPurified by affinity chromatography
Appearance/FormLiquid
FormulationPBS, 1% BSA, 50% Glycerol,0.02% Sodium azide
StorageStore as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Regulatory StatusResearch Use Only

Scientific Background

Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys-63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of TP53/p53 and an increase in TP53/p53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated TP53/p53 but not with MDM2 for proteasomal recognition.

Synonyms

ubiquitin specific peptidase 5 , ISOT

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