Ultra-LEAF™ Purified anti-human AXL Antibody, AXL, S21005F,BioLegend,648857

AXL is a receptor tyrosine kinase member of the TAM family that includes Tyro3, AXL, and Mer. The members of this family are type I receptors characterized by two immunoglobulin (Ig)-like and fibronectin III (FNIII) domains in the extracellular domain, a transmembrane domain, and a kinase intracellular domain. The TAM receptors have common ligands, such as GAS-6 and protein S. GAS-6 binds to the three receptors, meanwhile protein S binds only to Tyro3 and Mer. GAS-6 has the highest affinity for AXL, compared to Tyro3 and Mer. AXL is activated by different mechanisms: Gas-6-dependent dimerization, ligand-independent dimerization, and heteromeric dimerization with different receptors that are not members of the TAM family, such as IFNAR, EGFR, PDGFR, and FLT3. Soluble forms of AXL are present in human and murine plasma. They derived of the proteolytic cleavage of the extracellular domain. Soluble forms also bind to GAS-6, acting as inhibitors of AXL-mediated cell activation. AXL is overexpressed in many cancers, such as lung, breast, colon, gastric, ovarian, prostate, thyroid, myeloid leukemia, and chronic lymphocytic leukemia to mention some, and its expression has been associated with poor prognosis.