Ultra-LEAF™ Purified anti-human CCL19 (MIP-3β) Antibody, CCL19, A15093C,BioLegend,612803

Host

Mouse

Reactivity

Human

Application

Neut - Quality testedDirect ELISA - Verified

Platform ID

BAB109325643

BioLegend

Headquarters

8999 BioLegend Way San Diego, CA 92121 United States

BioLegend

Contact

Tel: 1-858-455-9588
Fax: +49 (4131) 7023913

Email:

Product Specifications
Scientific Background

Specifications

NameUltra-LEAF™ Purified anti-human CCL19 (MIP-3β) Antibody, CCL19, A15093C
Cat. No.612803
HostMouse
RRIDAB_2820099 (BioLegend Cat. No. 612803)AB_2820100 (BioLegend Cat. No. 612804)
IsotypeMouse IgG2b, κ
ReactivityHuman
ApplicationNeut - Quality testedDirect ELISA - Verified
ClonalityMonoclonal
Clone NumberA15093C
ConcentrationThe antibody is bottled at the concentration indicated on the vial, typically between 2 mg/mL and 3 mg/mL. Older lots may have also been bottled at 1 mg/mL. To obtain lot-specific concentration and expiration, please enter the lot number in ourCertificate of Analysisonline tool.
TargetCCL19
ImmunogenRecombinant Human CCL19
PurityThe Ultra-LEAF™ (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.
Formulation0.2 µm filtered in phosphate-buffered solution, pH 7.2, containing no preservative.
StorageThe antibody solution should be stored undiluted between 2°C and 8°C. This Ultra-LEAF™ solution contains no preservative; handle under aseptic conditions.
Regulatory StatusResearch Use Only

Scientific Background

CCL19 is a CC chemokine expressed in the lymph nodes. CCL19 is only 32% identical to CCL21 at the amino acid level; nevertheless, these chemokines bind to the same receptor, CCR7.  CCL19 is not expressed in high endothelial venules (HEV) as is CCL21, but CCL19 is transcytosed in HEV. It has been described that CCL19 binds to CCX-CKR and CRAM-B receptors. These two receptors are members of the non-classical chemokine receptor family, which also includes D6, DARC, and CXCR7. It has been suggested that CCX-CKR is a scavenging receptor for CCL19, and the CRAM-B receptor might be responsible for the transcytosis in HEV for CCL19. In addition, CRAM recycles constitutively and can internalize CCL19 within a few minutes, suggesting it may play a role in the regulation of immune responses as well as homing processes.

Category Paths

Request a product

Please provide the required information below so that we can quickly source your products.