Ultra-LEAF™ Purified anti-human CCL22 Antibody anti-CCL22 - A15083D,BioLegend,694403

Clones A15083A and A15083D do not block each otherClone A15083A does not block the reference clone T51-719 (BD Bioscience)Clones A15083A and A15083D showed good staining in both Cyto-Fast™ Fix/Perm Buffer Set and True-Phos™ Perm Buffer.

Host

Mouse

Reactivity

Human

Application

Neut - Quality testedICFC - Verified

Platform ID

BAB234288161

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Product Specifications
Scientific Background

Specifications

NameUltra-LEAF™ Purified anti-human CCL22 Antibody anti-CCL22 - A15083D
Cat. No.694403
HostMouse
RRIDAB_2650729 (BioLegend Cat. No. 694403)AB_2650730 (BioLegend Cat. No. 694404)
IsotypeMouse IgG2a, κ
ReactivityHuman
ApplicationNeut - Quality testedICFC - Verified
ClonalityMonoclonal
Clone NumberA15083D
ConcentrationThe antibody is bottled at the concentration indicated on the vial, typically between 2 mg/mL and 3 mg/mL. Older lots may have also been bottled at 1 mg/mL. To obtain lot-specific concentration and expiration, please enter the lot number in ourCertificate of Analysisonline tool.
TargetCCL22
ImmunogenHuman CCL22
PurityThe Ultra-LEAF™ (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.
Formulation0.2 µm filtered in phosphate-buffered solution, pH 7.2, containing no preservative.
StorageThe antibody solution should be stored undiluted between 2°C and 8°C. This Ultra-LEAF™ solution contains no preservative; handle under aseptic conditions.
Regulatory StatusResearch Use Only

Scientific Background

CCL22 is thymus-specific chemokine engaged in the recruitment of T cells. CCL22 is associated with different diseases such as allergen-induced lung inflammation, atopic dermatitis, and lymphoma. Also, high levels of CCL22 have been detected in the CNS in multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). In addition, CCR4+ T cells have been linked to endotoxic shock, rheumatoid arthritis, T cell lymphoma, and autoimmune diabetes. CCL22 is a prostaglandin-dependent pyrogen, acting in the anterior hypothalamus to induce hyperthermia via activation of brown adipose tissue.

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