Ultra-LEAF™ Purified anti-human CD117 (c-kit) Antibody, CD117, S18022H,BioLegend,380303
Binding of clone S18022H can block the binding of ligand to CD117 and can also induce c-kit downstream signaling, suggesting the possibility that clone S180022H may mimic ligand binding on c-kit.Clone S18022H does not affect the binding of clones S18022G, W18195C, W18195D or 104D2 binding to the target.Clone S18022H can block binding of clone W18195E on the target.
Host
Mouse
Reactivity
Human
Application
FC - Quality testedActiv - Verified
Platform ID
BAB133713931
BioLegend
Contact
Tel: 1-858-455-9588
Fax: +49 (4131) 7023913
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Product Specifications
Scientific Background
Specifications
NameUltra-LEAF™ Purified anti-human CD117 (c-kit) Antibody, CD117, S18022H
Cat. No.380303
HostMouse
RRIDAB_2922610 (BioLegend Cat. No. 380303)
IsotypeMouse IgG2a, κ
ReactivityHuman
ApplicationFC - Quality testedActiv - Verified
ClonalityMonoclonal
Clone NumberS18022H
ConcentrationThe antibody is bottled at the concentration indicated on the vial, typically between 2 mg/mL and 3 mg/mL. To obtain lot-specific concentration and expiration, please enter the lot number in ourCertificate of Analysisonline tool.
TargetCD117
ImmunogenHuman CD117 transfectant
PurityThe Ultra-LEAF™ (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.
Formulation0.2 µm filtered in phosphate-buffered solution, pH 7.2, containing no preservative.
StorageThe antibody solution should be stored undiluted between 2°C and 8°C. This Ultra-LEAF™ solution contains no preservative; handle under aseptic conditions.
Regulatory StatusResearch Use Only
Scientific Background
CD117 is a 145 kD protein tyrosine kinase also known as c-kit. It is a receptor for stem cell factor or c-kit ligand. CD117 is expressed on pluripotent hematopoietic progenitor cells (approximately 1-4% bone marrow cells), mast cells, and acute myeloid leukemia cells (AML). CD117 binding of c-kit ligand induces phosphorylation of CD117 and stimulates proliferation and survival of primitive hematopoietic stem cells as well as erythroid-committed and granulo-monocytic committed cells.
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
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